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Ischemic Stroke Incidence in Patients With Microvascular Ocular Motor Palsy Versus Patients With Lacunar Ischemic

José Beato-Coelho1, Ricardo Varela1, Luciano Almendra1

  • 1Neurology Department, Coimbra University Hospital Centre.

The Neurologist
|March 1, 2019
PubMed
Abstract

Insights

Patients experiencing microvascular ocular motor palsy (mOMP) face a similar risk of subsequent ischemic stroke as those with lacunar stroke (LS). This suggests mOMP may be an underrecognized stroke risk factor.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Ophthalmology

Background:

  • Microvascular ischemia is a primary cause of ocular motor palsy (OMP).
  • The incidence of subsequent ischemic stroke following microvascular OMP (mOMP) is not well-established.
  • Comparing mOMP to lacunar stroke (LS) provides a benchmark for ischemic stroke risk.

Purpose of the Study:

  • To compare the incidence of subsequent ischemic stroke in patients with mOMP versus LS.
  • To determine if mOMP is an independent risk factor for future ischemic stroke.

Main Methods:

  • Retrospective observational study of acute patients with mOMP or LS.
  • Propensity score matching used to balance patient groups.
  • Follow-up period of 80 months to assess subsequent ischemic stroke incidence.

Main Results:

  • Study included 110 patients (57 mOMP, 53 LS).
  • Annual ischemic stroke rates were 2.1% for mOMP and 0.6% for LS.
  • Cox regression revealed no statistically significant difference in subsequent ischemic stroke incidence between groups (P=0.801).

Conclusions:

  • Patients with presumed mOMP exhibit a similar incidence of subsequent ischemic stroke compared to patients with LS.
  • Presumed mOMP may represent an underrecognized independent risk factor for ischemic stroke.

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