Related Experiment Video
Updated: Jan 28, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
Oxidative stress injury in doxorubicin-induced cardiotoxicity
Mei Songbo1, Hong Lang2, Cai Xinyong2
1Department of Cardiology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, No, 92 Aiguo Road, Donghu District, Nanchang, 330006, Jiangxi, People's Republic of China; Medical Graduate school of Nanchang University, No, 461 Bayi Avenue, Donghu District, Nanchang, 330006, Jiangxi, People's Republic of China.
Abstract:
Doxorubicin (DOX) is widely used as a broad-spectrum anti-tumor anthracycline to treat various cancers. The serious adverse effects of DOX on cardiotoxicity limit its clinical application. There are several different mechanisms involved in DOX-induced cardiotoxicity. Oxidative stress (OS) is caused by an imbalance between reactive oxygen species (ROS) and endogenous antioxidants in response to injury, which can lead to myocardial toxicity. The aim of this review was to investigate the mechanisms underlying the effects of oxidative stress injury on myocardial toxicity, from three different aspects: the increase in downstream oxidative stress products, the reduction in upstream antioxidative stress products, and subcellular organelles. Finally, there are some anti-oxidative drugs that show efficacy in limiting DOX-induced cardiotoxicity. It is necessary to fully understand the toxicity of DOX to the myocardium and achieve symptomatic treatment.
Related Concept Videos
Oxidation Numbers
Pyruvate Oxidation
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
Oxidation-Reduction Reactions
Responses to Salt Stress
Responses to Heat and Cold Stress
General State of Stress
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...

