Photodimerization systems for regulating protein-protein interactions with light
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Updated: Jan 28, 2026

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Jessica I Spiltoir1, Chandra L Tucker1
1Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Abstract:
Optogenetic dimerizers are modular domains that can be utilized in a variety of versatile ways to modulate cellular biochemistry. Because of their modularity, many applications using these tools can be easily transferred to new targets without extensive engineering. While a number of photodimerizer systems are currently available, the field remains nascent, with new optimizations for existing systems and new approaches to regulating biological function continuing to be introduced at a steady pace.
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