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Circadian clock genes and circadian phenotypes in patients with myocardial infarction

Ivana Škrlec1, Jakov Milić2, Marija Heffer2

  • 1Department of Biology and Chemistry, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Osijek, Croatia; Department of Medical Biology and Genetics, Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia.

Advances in Medical Sciences
|March 1, 2019
PubMed

Insights

Genetic variations in circadian clock genes are linked to chronotype and daytime sleepiness in myocardial infarction (MI) patients. These findings highlight potential genetic factors influencing circadian phenotypes in heart disease.

Area of Science:

  • Genetics
  • Chronobiology
  • Cardiology

Background:

  • Circadian rhythms regulate human physiology and disease.
  • Disrupted circadian rhythms and sleep duration are linked to various diseases.
  • Sleep disorders are associated with adverse vascular outcomes, including myocardial infarction (MI).

Purpose of the Study:

  • To investigate the association between circadian clock gene variants and circadian phenotypes in patients with MI.
  • To explore genotype-phenotype interactions related to chronotype and sleepiness in MI.
  • To identify specific single nucleotide polymorphisms (SNPs) in circadian clock genes associated with MI phenotypes.

Main Methods:

  • An association study analyzing genotype-phenotype interactions.
  • Examined allele frequencies of 10 SNPs in four circadian clock genes.
  • Utilized the Morningness-Eveningness Questionnaire (MEQ) for chronotype and Epworth Sleepiness Scale (ESS) for daytime sleepiness in MI patients and controls.

Main Results:

  • A significant association was found between chronotype and the ARNTL gene variant rs12363415 in MI patients.
  • The CLOCK gene polymorphism rs11932595 and the PER2 gene polymorphism rs934945 were associated with daytime sleepiness in the MI patient group.

Conclusions:

  • Genetic variations in specific circadian clock genes may influence chronotype and daytime sleepiness in individuals with myocardial infarction.
  • These findings suggest a potential genetic link between circadian rhythm regulation and cardiovascular health.
  • Further research into circadian clock gene variants could offer insights into MI pathogenesis and personalized medicine approaches.
Abstract

Keywords:
Cardiovascular diseasesChronotypeCircadian rhythmClock genesMyocardial infarction

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