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Tinnitus during and after childhood cancer: A systematic review

Annelot J M Meijer1, Eva Clemens2, Alex E Hoetink3

  • 1Department of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.

Critical Reviews in Oncology/Hematology
|March 2, 2019
PubMed
Abstract

Insights

Childhood cancer survivors face a higher risk of tinnitus. High-dose cranial radiation and platinum chemotherapy are key risk factors, necessitating regular tinnitus screening for early detection and management.

Area of Science:

  • Pediatric Oncology
  • Otolaryngology
  • Cancer Survivorship

Background:

  • Tinnitus is a known complication during and after childhood cancer treatment.
  • Limited research exists on tinnitus occurrence and risk factors in this population.
  • This study reviews existing literature to understand tinnitus prevalence and associated risks.

Purpose of the Study:

  • To determine the frequency of tinnitus in childhood cancer patients during and after treatment.
  • To identify risk factors associated with tinnitus development in this cohort.
  • To provide evidence for improved screening and management strategies.

Main Methods:

  • Systematic literature search across major databases (EMBASE, Medline, Cochrane, Web of Science, Google Scholar).
  • Inclusion criteria: studies on tinnitus in patients under 25 at diagnosis with childhood malignancy treated with chemotherapy/radiotherapy.
  • Risk of bias assessment was conducted for included studies.

Main Results:

  • Tinnitus incidence rates up to 15.9% during therapy and 5.4% after 5 years.
  • Relative risk of tinnitus up to 17.2 during therapy and 3.7 after 5 years compared to siblings.
  • High-dose cranial radiation and platinum-based chemotherapy identified as independent risk factors.

Conclusions:

  • Childhood cancer patients and survivors exhibit a higher risk of tinnitus compared to the general population.
  • Regular tinnitus screening using standardized questionnaires is recommended before, during, and after therapy.
  • Early detection can facilitate the development of preventive and management strategies for high-risk patients.
Keywords:
Cancer treatmentChildhood cancerDirect toxicityLate effectsOtotoxicityTinnitus

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