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A Hydroponic Co-cultivation System for Simultaneous and Systematic Analysis of Plant/Microbe Molecular Interactions and Signaling
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Engineering Robust Production Microbes for Large-Scale Cultivation
Maren Wehrs1, Deepti Tanjore2, Thomas Eng3
1Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Institut für Genetik, Technische Universität Braunschweig, Braunschweig, Germany; Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.
Trends in Microbiology
|March 2, 2019
Summary
Systems biology and synthetic biology offer solutions for scaling up microbial production. These approaches help engineer robust microbes by understanding and improving strain responses to large-scale bioreactor conditions.
Area of Science:
- Microbial biotechnology
- Systems biology
- Synthetic biology
Background:
- Scaling up microbial production presents challenges due to differences between lab and industrial settings.
- Strain characteristics crucial for large-scale processes require careful consideration.
Purpose of the Study:
- To review the application of systems biology and synthetic biology in addressing scale-up challenges in microbial production.
- To highlight strain attributes important for large-scale fermentation.
Main Methods:
- Review of systems biology studies on microbial responses to bioreactor conditions (nutrients, gases, stresses).
- Review of synthetic biology applications for assessing, modulating, and engineering microbial strains.
- Analysis of laboratory vs. large-scale culture differences.
Main Results:
- Systems biology tools effectively analyze microbial behavior under bioreactor stresses.
- Synthetic biology enables strain engineering for enhanced production and robustness.
- Key strain characteristics for scale-up have been identified.
Conclusions:
- Systems and synthetic biology are vital for engineering robust microbes for industrial-scale production.
- These disciplines provide a framework for optimizing microbial processes from lab to large scale.
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