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Related Concept Videos

Electrical Current01:10

Electrical Current

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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Protein Complex Assembly02:41

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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How Data are Classified: Numerical Data00:59

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Data that are countable or measurable in specific units are called numerical or quantitative data. Quantitative data are always numbers. Quantitative data are the result of counting or measuring the attributes of a population. Amount of money, pulse rate, weight, number of people living in a town, and number of students who opt for statistics are examples of quantitative data.
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Protein Complexes with Interchangeable Parts01:57

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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How Data are Classified: Categorical Data01:11

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A variable, usually notated by capital letters such as X and Y, is a characteristic or measurement that can be determined for each member of a population. Data are the actual values of variables. They may be numbers, or they may be words. Datum is a single value.
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Significance of Displacement Current01:27

Significance of Displacement Current

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A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
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[Tumor banks and complex data management: Current and future challenges].

Paul Hofman1, Georges Dagher2, Pierre Laurent-Puig3

  • 1Laboratoire de pathologie clinique et expérimentale, hôpital Pasteur, université Côte d'Azur, CHU de Nice, BP 69, 30, avenue de la Voie-Romaine, 06001 Nice cedex 01, France; Biobanque hospitalière (BB-0033-00025), hôpital Pasteur, université Côte d'Azur, CHU de Nice, BP 69, 30, avenue de la Voie-Romaine, 06001 Nice cedex 01, France; FHU OncoAge, hôpital Pasteur, université Côte d'Azur, CHU de Nice, BP 69, 30, avenue de la Voie-Romaine, 06001 Nice cedex 01, France.

Annales De Pathologie
|March 2, 2019
PubMed
Summary

Tumor banks are evolving into professional entities crucial for biomarker research in oncology. They face challenges in data integration and sustainability, requiring optimization to remain competitive internationally.

Keywords:
Big dataBiobanksBiobanqueChallengesDonnées massivesDéfisOncologieOncology

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Area of Science:

  • Oncology
  • Biotechnology
  • Pathology

Background:

  • Tumor banks are essential for clinical and translational research in oncology.
  • They play a critical role in the assessment and validation of diagnostic, prognostic, and predictive biomarkers.
  • The field is undergoing professionalization, recognizing biobanks as key players in oncology.

Purpose of the Study:

  • To review the current evolution of biobanks.
  • To outline the present and future challenges faced by biobanks.
  • To define the role of pathologists in addressing these challenges within oncology.

Main Methods:

  • Literature review on biobank evolution and challenges.
  • Analysis of the impact of biotechnologies and therapeutics on biobanks.
  • Examination of the integration of complex clinical and biological data.

Main Results:

  • Biobanks are increasingly professionalized and recognized as key stakeholders.
  • Advances in biotechnology and therapeutics are reshaping biobank operations and impact.
  • Data integration and sustainability are significant current challenges for biobanks.

Conclusions:

  • Biobanks require optimization to enhance their role and international competitiveness.
  • Pathologists are integral to navigating the evolving landscape of biobanks in oncology.
  • Addressing sustainability and data complexity is crucial for the future of biobanking in cancer research.