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Microvascular Rarefaction and Myocardial Fibrosis in Hypertrophic Obstructive Cardiomyopathy

Hongwei Tian1, Chengzhi Yang1, Yunhu Song1

  • 1State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cardiology
|March 2, 2019
PubMed

Insights

Hypertrophic obstructive cardiomyopathy (HOCM) involves increased fibrosis and reduced microvascular density (MVD). This study found a negative correlation between fibrosis severity and MVD in HOCM, suggesting reduced MVD contributes to myocardial fibrosis.

Area of Science:

  • Cardiology
  • Pathology
  • Medical Research

Background:

  • Hypertrophic obstructive cardiomyopathy (HOCM) is a myocardial disease characterized by fibrosis and microvascular ischemia.
  • The role of microvascular density (MVD) in the progression of myocardial fibrosis in HOCM is not fully understood.

Purpose of the Study:

  • To investigate the relationship between microvascular density (MVD) and myocardial fibrosis in patients with HOCM.

Main Methods:

  • Analysis of myectomy left ventricular septal wall specimens from 53 HOCM patients and 9 control subjects.
  • Quantification of microvascular density (MVD) and fibrosis ratio using histological analysis.
  • Correlation analysis between MVD, fibrosis, and late gadolinium enhancement.

Main Results:

  • HOCM patients exhibited significantly higher fibrosis ratios and lower MVD compared to controls.
  • A significant negative correlation was observed between the severity of myocardial fibrosis and MVD in HOCM patients.
  • Late gadolinium enhancement showed a negative correlation with MVD and a positive correlation with fibrosis.

Conclusions:

  • HOCM is associated with increased myocardial fibrosis and reduced MVD.
  • Reduced MVD may be a contributing factor to the development of myocardial fibrosis in HOCM.
  • These findings highlight the intricate relationship between microvasculature and fibrosis in HOCM pathogenesis.
Abstract

Keywords:
Hypertrophic obstructive cardiomyopathyMicrovascular densityMyocardial fibrosis

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