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Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells
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Germ Cell Tumors with Malignant Somatic Transformation: A Mayo Clinic Experience

Caleb J Scheckel, Heidi E Kosiorek, Richard Butterfield

    Oncology Research and Treatment
    |March 2, 2019
    PubMed
    Abstract

    Insights

    Malignant somatic transformation (MST) in germ cell tumors (GCTs) is rare, with poor response to standard chemotherapy. Targeted therapies and surgical resection are crucial for managing these aggressive GCTs.

    Area of Science:

    • Oncology
    • Pathology
    • Genitourinary Cancers

    Background:

    • Germ cell tumors (GCTs) with malignant somatic transformation (MST) are uncommon, with limited data on outcomes.
    • Understanding MST subtypes and their impact on treatment response is critical.

    Purpose of the Study:

    • To analyze the characteristics, treatment, and survival of patients with GCTs and MST.
    • To identify optimal management strategies for GCTs with MST.

    Main Methods:

    • Retrospective review of 24 GCTs with MST cases from 1982-2017.
    • Extraction of patient demographics, pathology, treatment, and clinical outcomes.

    Main Results:

    • MST subtypes were equally adenocarcinoma and sarcoma (50% each).
    • Most patients had advanced stage (71% stage III) disease.
    • Median progression-free survival was 84 months; median overall survival was 219 months.

    Conclusions:

    • GCTs with MST show poor response to cisplatin-based chemotherapy.
    • Somatic component-driven therapies and surgical resection of residual disease are recommended.
    Keywords:
    GCTGerm cell tumorMSTMalignant somatic transformationTesticular cancer

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