Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fibronectin in severe sepsis.

L E Stevens, T P Clemmer, R M Laub

    Surgery, Gynecology & Obstetrics
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor.

    International journal of obesity (2005)·2016
    Same author

    Targeted next-generation sequencing in the diagnosis of neurodevelopmental disorders.

    Clinical genetics·2014
    Same author

    c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.

    Oncogene·2010
    Same author

    Risk-reducing surgery in FAP: role for surgeons beyond the incision.

    Journal of surgical oncology·2010
    Same author

    Adaptation of USP types II and IV controlled release assays for sparingly soluble compounds by direct eluent HPLC analysis.

    Pharmaceutical development and technology·2006
    Same author

    Results of intervention for lupus patients with self-perceived cognitive difficulties.

    Neurology·2005

    This study found that fibronectin cryoprecipitate improved survival rates in patients with severe surgical sepsis. Treatment with fibronectin also increased serum fibronectin levels, suggesting a potential therapeutic benefit.

    Area of Science:

    • Critical Care Medicine
    • Hematology
    • Surgical Pathology

    Background:

    • Severe surgical sepsis is associated with significantly reduced survival rates.
    • Patients with sepsis often exhibit depressed serum fibronectin levels.
    • Fibronectin plays a crucial role in immune response and tissue repair.

    Purpose of the Study:

    • To investigate the efficacy of fibronectin cryoprecipitate in improving outcomes for patients with severe surgical sepsis.
    • To assess the impact of fibronectin administration on serum fibronectin levels in septic patients.

    Main Methods:

    • A double-blind, prospective, randomized clinical study was conducted.
    • Patients with severe surgical sepsis were assigned to either a control group (no fibronectin) or a treatment group (fibronectin cryoprecipitate).

    Related Experiment Videos

  • Serum fibronectin levels, survival rates, and other clinical parameters were monitored.

    • Main Results:

    • The fibronectin treatment group showed a higher survival rate (75%) compared to the control group (42%) (p < 0.05).
    • Administration of fibronectin cryoprecipitate increased serum fibronectin levels in treated patients.
    • While improvements were observed in pulmonary function and organ markers, they did not reach statistical significance.

    Conclusions:

    • Fibronectin cryoprecipitate shows promise as a beneficial treatment for severe surgical sepsis, particularly in improving survival.
    • Further research with larger patient cohorts is warranted to confirm these findings and explore other potential benefits.