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A Mouse Model of Postoperative Pain.
Ashley M Cowie1, Cheryl L Stucky1
1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Bio-Protocol
|March 2, 2019
Summary
Developing non-opioid pain therapeutics is crucial due to the opioid crisis. This study details a reproducible mouse model for investigating postoperative pain mechanisms and identifying new treatments.
Area of Science:
- Pain research
- Neuroscience
- Pharmacology
Background:
- Postoperative pain significantly impedes patient recovery.
- Opioids are primary treatments but carry risks of addiction and overdose.
- There is an urgent need for effective non-opioid pain management strategies.
Purpose of the Study:
- To establish a reliable mouse model for studying incisional postoperative pain.
- To facilitate the development of novel, non-opioid pain therapeutics.
- To investigate the underlying mechanisms of postoperative pain in the nervous system.
Main Methods:
- Adaptation and detailed description of a mouse model for incisional pain.
- Utilizing established protocols for reproducibility.
- Inducing peripheral and central nervous system alterations characteristic of pain.
Main Results:
- The described model is frequently used and highly reproducible.
- The model effectively replicates key aspects of postoperative pain.
- Demonstrates induction of nervous system alterations relevant to pain.
Conclusions:
- The established mouse model is a valuable tool for postoperative pain research.
- This model supports the search for non-opioid pain relief.
- Further investigation into pain mechanisms is enabled by this protocol.
Keywords:
HypersensitivityInflammatory painMousePlantar incisionPostoperative painSkin and muscle incisionMore Related Videos
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