Related Experiment Video

Updated: Jan 28, 2026

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse
09:26

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

Published on: May 16, 2016

37.8K

A Mouse Model of Postoperative Pain

Ashley M Cowie1, Cheryl L Stucky1

  • 1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Bio-Protocol
|March 2, 2019
PubMed

Insights

Developing non-opioid pain therapeutics is crucial due to the opioid crisis. This study details a reproducible mouse model for investigating postoperative pain mechanisms and identifying new treatments.

Area of Science:

  • Pain research
  • Neuroscience
  • Pharmacology

Background:

  • Postoperative pain significantly impedes patient recovery.
  • Opioids are primary treatments but carry risks of addiction and overdose.
  • There is an urgent need for effective non-opioid pain management strategies.

Purpose of the Study:

  • To establish a reliable mouse model for studying incisional postoperative pain.
  • To facilitate the development of novel, non-opioid pain therapeutics.
  • To investigate the underlying mechanisms of postoperative pain in the nervous system.

Main Methods:

  • Adaptation and detailed description of a mouse model for incisional pain.
  • Utilizing established protocols for reproducibility.
  • Inducing peripheral and central nervous system alterations characteristic of pain.

Main Results:

  • The described model is frequently used and highly reproducible.
  • The model effectively replicates key aspects of postoperative pain.
  • Demonstrates induction of nervous system alterations relevant to pain.

Conclusions:

  • The established mouse model is a valuable tool for postoperative pain research.
  • This model supports the search for non-opioid pain relief.
  • Further investigation into pain mechanisms is enabled by this protocol.
Keywords:
HypersensitivityInflammatory painMousePlantar incisionPostoperative painSkin and muscle incision

More Related Videos

Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model06:20

Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model

Published on: September 1, 2023

1.7K
A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

30.5K

Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
396
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.6K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.5K
Primary Motives: Sleep, Sex, and Pain Avoidance01:24

Primary Motives: Sleep, Sex, and Pain Avoidance

Primary motives such as sleep, sex, and pain avoidance are crucial drivers of behavior in humans and animals. These motives ensure survival, reproductive success, and overall well-being by prompting actions that meet essential bodily needs.
Sleep is a fundamental physiological drive that fosters a state of restfulness crucial for several bodily functions. It facilitates body restoration, the process by which the body repairs, rejuvenates, and maintains itself during sleep, including memory...
5.5K
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.7K