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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
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Dichroism-sensitive photoacoustic computed tomography.

Yuan Qu1, Lei Li2, Yuecheng Shen2

  • 1Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.

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|March 2, 2019
PubMed
Summary

This study introduces dichroism-sensitive photoacoustic computed tomography (DS-PACT) for deep tissue imaging. DS-PACT measures tissue absorption anisotropy and optic axis orientation, enhancing PACT

Keywords:
(100.1930) Dichroism(170.3880) Medical and biological imaging(170.5120) Photoacoustic imaging(260.5855) Scattering, polarization

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Area of Science:

  • Biomedical optics
  • Medical imaging
  • Photoacoustics

Background:

  • Photoacoustic computed tomography (PACT) images optical absorption for deep tissue visualization.
  • Standard PACT assumes scalar absorption coefficients, neglecting tissue anisotropy.
  • Biological tissues often exhibit dichroism/diattenuation due to molecular alignment.

Purpose of the Study:

  • To develop a novel imaging method, dichroism-sensitive PACT (DS-PACT).
  • To measure both the amplitude of tissue dichroism and the optic axis orientation.
  • To extend PACT capabilities for imaging tissue absorption anisotropy.

Main Methods:

  • DS-PACT modulates linearly polarized light and uses lock-in detection.
  • This technique enhances the detection of dichroic signals from biological tissues.
  • Experimental validation involved imaging plastic polarizers and ex vivo bovine tendons.

Main Results:

  • DS-PACT successfully measured the orientation of the optic axis in uniaxial dichroic materials.
  • Effective imaging was achieved deep within scattering media (4.5 transport mean free paths).
  • The method demonstrated sensitivity to absorption anisotropy.

Conclusions:

  • DS-PACT enables quantitative measurement of tissue absorption anisotropy.
  • The technique can determine the orientation of the optic axis in dichroic tissues.
  • DS-PACT significantly expands the functional imaging capacity of PACT.