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Association of Aspirin Resistance with Increased Mortality in Ischemic Stroke

Y Jing1, X Yue, S Yang

  • 1Xincan Yue, No. 26 Renmin Road East, Zhoukou, 466000, Henan Province, P. R. China, E-mail: 365201720@qq.com; Tel: +86-0394-8269178; Fax: 86-0394-8269178.

The Journal of Nutrition, Health & Aging
|March 2, 2019
PubMed

Insights

Aspirin resistance (AR) is linked to higher mortality in Chinese patients with acute ischemic stroke (AIS). This study found AR predicts both all-cause and cardiovascular disease mortality, highlighting its prognostic value.

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Aspirin is a cornerstone therapy for acute ischemic stroke (AIS).
  • Aspirin resistance (AR) may impact patient outcomes.
  • Prognostic markers for mortality in AIS are crucial for patient management.

Purpose of the Study:

  • To investigate the association between aspirin resistance (AR) and mortality in Chinese patients with acute ischemic stroke (AIS).
  • To determine if AR is a useful prognostic marker for all-cause and cardiovascular disease (CVD) mortality in this cohort.

Main Methods:

  • A cohort of 196 Chinese patients with AIS, treated with aspirin for at least 7 days prior to stroke, was analyzed.
  • All-cause and CVD mortality were assessed at 1-year follow-up.
  • Logistic regression models were used to evaluate the relationship between AR and mortality outcomes.

Main Results:

  • The prevalence of AR was 17.9% in the study cohort.
  • Patients with AR exhibited significantly higher median NIHSS scores and infarct volumes compared to those without AR.
  • AR was significantly associated with increased all-cause mortality (OR=3.15) and CVD mortality (OR=3.31) after adjusting for other predictors.

Conclusions:

  • Aspirin resistance is a significant independent predictor of mortality in Chinese patients with AIS.
  • AR serves as a valuable prognostic marker for both all-cause and cardiovascular disease mortality.
  • These findings underscore the importance of considering AR in the risk stratification and management of AIS patients.
Abstract

Keywords:
Aspirin resistancecardiovascular diseaseischemic strokemortality

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