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Updated: Jan 28, 2026

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
Published on: June 23, 2018
Stress-induced protein aggregates shape population heterogeneity in bacteria
Julien Mortier1, Wubishet Tadesse1, Sander K Govers1,2
1Department of Microbial and Molecular Systems (M²S), KU Leuven, 3001, Leuven, Belgium.
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The concept of phenotypic heterogeneity preparing a subpopulation of isogenic cells to better cope with anticipated stresses has been well established. However, less is known about how stress itself can drive subsequent cellular individualization in clonal populations. In this perspective, we focus on the impact of stress-induced cellular protein aggregates, and how their segregation and disaggregation can act as a deterministic incentive for heterogeneity in the population emerging from a stressed ancestor.
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