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Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression

Hsi-Feng Tu1,2, Michael Yuanchien Chen3,4, Joseph Chieh-Yui Lai5

  • 1Department of Dentistry, School of Dentistry, National Yang-Ming University, Taipei, Taiwan.

Head & Neck
|March 2, 2019
PubMed
Abstract

Insights

Arecoline affects Ataxia telangiectasia mutated (ATM) expression differently in oral cancer stages. High ATM protects pre-cancerous cells, while low ATM promotes oral cancer progression and malignancy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Ataxia telangiectasia mutated (ATM) is crucial for DNA repair and cell cycle regulation.
  • Oral cancer progression involves complex molecular changes, including alterations in ATM expression.

Purpose of the Study:

  • To investigate the role of arecoline in modulating ATM expression during oral cancer development.
  • To analyze the correlation between ATM expression levels and oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC).

Main Methods:

  • In vitro studies using OSCC cell lines treated with varying doses of arecoline.
  • In vivo analysis of ATM expression in normal, OPMD, and OSCC tissues via immunohistochemistry.

Main Results:

  • Low-dose arecoline promoted cell proliferation and DNA repair via ATM activation.
  • High-dose arecoline induced cell cycle arrest, apoptosis, and DNA damage.
  • ATM was upregulated in OPMD but downregulated in OSCC, correlating with dysplasia risk, tumor location, and survival rates.

Conclusions:

  • Elevated ATM expression in OPMD facilitates DNA repair, maintaining cellular stability.
  • Decreased ATM expression in OSCC leads to accumulated DNA damage, promoting malignancy and poor prognosis.
Keywords:
DNA repairarecolineataxia telangiectasia mutated (ATM)oral potentially malignant disorder (OPMD)oral squamous cell carcinoma (OSCC)

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