Related Experiment Video For , Epstein–Barr virus
Updated: Jan 28, 2026

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
Clinicopathological, immune and molecular correlates of PD-L2 methylation in gastric adenocarcinomas
Philipp Lingohr1, Jonas Dohmen1, Alexander Semaan1
1Department of Surgery, University Hospital Bonn, Bonn, Germany.
Abstract:
Aim: We investigated the significance of PD-L2 DNA methylation in gastric adenocarcinomas. Methods: We analyzed the methylation at different CpG sites within the PD-L2-encoding gene PDCD1LG2 with regard to correlations and associations with gene expression, clinicopathological parameters, molecular features and immune cell infiltrates in two publicly available cohorts (The Cancer Genome Atlas and Singapore cohorts) of a total of 594 gastric adenocarcinoma patients. Results:PD-L2 methylation is significantly associated with transcriptional activity, survival, Epstein-Barr virus infection, PD-L2 gene amplification, CD8+ T-cell infiltration, microsatellite instability and high mutational load (tumor mutational burden, hypermutation). Conclusion:PD-L2 methylation is associated with known predictive biomarkers of response to anti-PD-1 immunotherapies.
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