Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

8.7K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.7K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

3.1K
3.1K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

2.7K
2.7K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

7.3K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.3K
The Evidence for Evolution02:55

The Evidence for Evolution

48.0K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.0K
Other Unique Bacteria01:18

Other Unique Bacteria

434
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
434

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liver Retransplantation in Pediatric Recipients: A 20-Year Single-Center Experience With 25 Cases.

Pediatric transplantation·2026
Same author

Strengthening infectious disease surveillance and control through long-term international collaboration: Insights from the Ghana- Japan partnership.

GHM open·2026
Same author

Incidental Hepatoblastoma in an Infant Who Underwent Liver Transplantation for Cryptogenic Liver Cirrhosis: A Case Report.

Pediatric transplantation·2026
Same author

Left Gastric Vein Anatomical Variation as a Determinant of Portal Vein Remodeling and Reconstructive Complexity in Infant Liver Transplantation.

Transplantation·2026
Same author

Utilization of meat juice from market-purchased pork for serological surveillance of mosquito-borne arboviruses.

The Journal of veterinary medical science·2026
Same author

The Selection of an Interposition Graft for Portal Vein Reconstruction: Maximizing the Availability of Autologous Vessels.

Pediatric transplantation·2026

Related Experiment Video

Updated: Jan 28, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

30.1K

Cooperation between different variants: A unique potential for virus evolution.

Yuta Shirogane1, Shumpei Watanabe2, Yusuke Yanagi1

  • 1Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.

Virus Research
|March 2, 2019
PubMed
Summary
This summary is machine-generated.

RNA virus quasispecies evolve through internal interactions between variants, not just individual mutations. Understanding these interactions and bloc transmission offers strategies against drug resistance and immune evasion.

Keywords:
Bloc transmissionCollective infectious unitCooperationDefective interferenceInternal interactionsQuasispecies

More Related Videos

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

5.2K
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

12.2K

Related Experiment Videos

Last Updated: Jan 28, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

30.1K
Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

5.2K
Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

12.2K

Area of Science:

  • Virology
  • Molecular Biology
  • Evolutionary Biology

Background:

  • RNA viruses exist as complex quasispecies due to error-prone RNA-dependent RNA polymerases.
  • Quasispecies dynamics involve internal interactions among viral variants, conferring unique evolvability.
  • Cooperation between wild-type and mutant viral genomes can lead to novel phenotypes.

Purpose of the Study:

  • To explore the mechanisms of internal interactions within RNA virus quasispecies.
  • To investigate the role of bloc transmission in viral evolution.
  • To identify how understanding viral evolution can address challenges like drug resistance and immune evasion.

Main Methods:

  • Review of recent studies on viral quasispecies and genome transmission.
  • Analysis of cooperative interactions between viral variants (e.g., wild-type and defective measles viruses).
  • Examination of mechanisms facilitating simultaneous transmission of multiple viral genomes (bloc transmission).

Main Results:

  • Internal interactions among viral variants enhance quasispecies evolvability beyond simple variant collections.
  • Co-transmission of multiple genomes, via polyploid virions, high multiplicity of infection, or bloc transmission, supports these interactions.
  • Bloc transmission mechanisms strengthen the concept of internal interactions in viral quasispecies.

Conclusions:

  • Understanding RNA virus quasispecies evolution, including internal interactions and bloc transmission, is crucial.
  • These evolutionary insights can inform strategies to combat viral drug resistance and immune evasion.
  • Further elucidation of these mechanisms may aid in controlling viral tropism and host range expansion.