Related Experiment Video
Updated: Jan 28, 2026
10:39
Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
Published on: December 7, 2011
15.6K
Spinal Epidural Lipomatosis: Weight Loss Cure
Sokol Trungu1, Stefano Forcato1, Antonino Raco2
1Neurosurgery Unit, Card. G. Panico Hospital, Tricase, Italy; N.E.S.M.O.S. Department, Faculty of Medicine and Psychology, ''Sapienza,'' University of Rome, Sant'Andrea Hospital, Rome, Italy.
World Neurosurgery
|March 2, 2019
Summary
Obesity-induced spinal epidural lipomatosis can cause neurogenic claudication. Significant weight loss led to full recovery and resolution of spinal epidural lipomatosis in this patient.
Area of Science:
- Neurosurgery
- Spinal Disorders
- Obesity Medicine
Background:
- Spinal epidural lipomatosis (SEL) is characterized by excessive fat accumulation in the epidural space.
- SEL can lead to neurological deficits, including neurogenic claudication, due to spinal cord or nerve root compression.
- Obesity is a significant risk factor for the development of SEL.
Observation:
- A 47-year-old male with a history of low back and lower extremity pain presented with neurogenic claudication.
- Initial assessment revealed a body mass index (BMI) of 38, indicative of severe obesity.
- Lumbar spine magnetic resonance imaging (MRI) confirmed severe spinal stenosis attributed to SEL.
Findings:
- Conservative management was initiated, focusing on lifestyle modifications.
- The patient achieved substantial weight loss over 13 months, reducing his BMI to 29.
- Following weight loss, complete resolution of neurological symptoms and significant reduction in SEL were observed on follow-up MRI.
Implications:
- Weight loss is a viable and effective conservative treatment for SEL-induced neurogenic claudication.
- Management of obesity is crucial in preventing and treating SEL.
- This case highlights the potential for non-surgical interventions to reverse severe spinal stenosis caused by SEL.
Related Concept Videos
01:20Curing of Concrete
369
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
369
01:26Curing Methods
293
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
293
01:25Accelerated Curing of Concrete
472
Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
472
01:10Line Loss
541
The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
541
00:57Weighted Mean
6.3K
While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others.
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
6.3K
01:18Reducing Line Loss
385
In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
385