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Hospitalization as a trigger for venous thromboembolism - Results from a population-based case-crossover study
Esben Bjøri1, Håkon S Johnsen1, John-Bjarne Hansen2
1K.G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Thrombosis Research
|March 2, 2019
Summary
Hospitalization significantly increases the risk of venous thromboembolism (VTE), even without immobilization. Immobilization further elevates this risk substantially in hospitalized patients, highlighting key VTE triggers.
Area of Science:
- Medical research
- Clinical epidemiology
- Thrombosis studies
Background:
- Venous thromboembolism (VTE) affects many patients post-hospitalization.
- Limited research exists on hospitalization as a specific VTE trigger.
Purpose of the Study:
- To assess hospitalization's impact on VTE risk.
- To evaluate the role of immobilization during hospitalization as a VTE trigger.
Main Methods:
- Case-crossover study involving 530 cancer-free VTE patients.
- Analyzed hospitalizations within 90 days before VTE diagnosis.
- Used conditional logistic regression to determine odds ratios (OR) for VTE.
Main Results:
- Hospitalization in the 90-day hazard period yielded an OR of 9.4 for VTE.
- Risk increased with hospitalization duration and frequency.
- Hospitalization without immobilization had an OR of 6.3; with immobilization, the OR was 19.8.
Conclusions:
- Hospitalization is a significant VTE trigger, independent of immobilization.
- Immobilization during hospitalization markedly increases VTE risk.
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