Related Experiment Video
Updated: Jan 28, 2026

Optimizing Sample Preparation Process for Transmission Electron Microscopy of Neuromuscular Junctions in Drosophila Larvae
Published on: September 15, 2023
Cholesterol and the Safety Factor for Neuromuscular Transmission
Igor I Krivoi1, Alexey M Petrov2,3
1Department of General Physiology, St. Petersburg State University, St. Petersburg 199034, Russia. iikrivoi@gmail.com.
Abstract:
A present review is devoted to the analysis of literature data and results of own research. Skeletal muscle neuromuscular junction is specialized to trigger the striated muscle fiber contraction in response to motor neuron activity. The safety factor at the neuromuscular junction strongly depends on a variety of pre- and postsynaptic factors. The review focuses on the crucial role of membrane cholesterol to maintain a high efficiency of neuromuscular transmission. Cholesterol metabolism in the neuromuscular junction, its role in the synaptic vesicle cycle and neurotransmitter release, endplate electrogenesis, as well as contribution of cholesterol to the synaptogenesis, synaptic integrity, and motor disorders are discussed.
Related Concept Videos
Cholesterol: Significance and Regulation
Considering cholesterol and...
Survey Safety
The Neuromuscular Junction
Household Wiring And Electrical Safety
Transcription Factors
Neuromuscular Junction And Blockade

