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High-throughput Antiviral Assays to Screen for Inhibitors of Zika Virus Replication
Published on: October 30, 2021
Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication
Rossella Gratton1, Almerinda Agrelli2, Paola Maura Tricarico3
1Department of Advanced Diagnostics, IRCCS Burlo Garofolo, Via dell'Istria 65/1, 34137 Trieste, Italy. rossella.gratton@gmail.com.
Abstract:
Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradation-considered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.
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