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Disseminated Bartonella henselae Infection Visualized by [18F]FDG-PET/CT and MRI

Marie Norredam1, Andreas Knudsen2, Carsten Thomsen3

  • 1Department of Infectious Diseases, University Hospital Hvidovre, 2800 Copenhagen, Denmark. mano@sund.ku.dk.

Diagnostics (Basel, Switzerland)
|March 3, 2019
PubMed

Insights

A rare case of disseminated Bartonella henselae infection in an immunosuppressed Crohn's disease patient was diagnosed using advanced imaging. Treatment with Doxycycline and Rifampicin led to complete recovery.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Radiology

Background:

  • Immunosuppressed patients with Crohn's disease are susceptible to opportunistic infections.
  • Fever of unknown origin (FUO) in this population requires thorough investigation.
  • Disseminated Bartonella henselae infection can mimic other serious conditions like malignancy.

Purpose of the Study:

  • To report a rare case of disseminated Bartonella henselae infection.
  • To highlight the utility of advanced imaging in diagnosing complex infections.
  • To emphasize the importance of considering zoonotic infections in immunocompromised individuals.

Main Methods:

  • Clinical case presentation of a 24-year-old male with Crohn's disease.
  • Diagnostic workup including [18F]FDG-PET/CT and MRI with contrast.
  • Liver biopsy for histopathology and PCR for pathogen identification.

Main Results:

  • Multifocal osteitis, abscesses, and organ involvement were visualized on PET/CT and MRI.
  • Liver biopsy revealed necrotizing granulomatous inflammation.
  • PCR confirmed Bartonella henselae infection, linked to cat exposure.

Conclusions:

  • Disseminated Bartonella henselae infection can present with diverse findings in immunocompromised patients.
  • [18F]FDG-PET/CT and MRI are valuable tools for diagnosing such infections.
  • Prompt antibiotic treatment (Doxycycline, Rifampicin) resulted in complete recovery.
Keywords:
MRI[18F]FDG-PET/CTdisseminated Bartonella henselae infection

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