Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

2-14C-mevalonate oxidation during rat development.

P Hahn

    Biology of the Neonate
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    In young rats, mevalonate oxidation increases with age. Kidney cells show consistent mevalonate oxidation, but male rats exhibit a temporary increase during weaning.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Defect coverage of fingers and thumb : Indications and treatment].

    Der Unfallchirurg·2018
    Same author

    Decompression for cervical disc herniation using the full-endoscopic anterior technique.

    Operative Orthopadie und Traumatologie·2018
    Same author

    [Decompression for cervical disc herniation using the full-endoscopic anterior technique - German version].

    Operative Orthopadie und Traumatologie·2018
    Same author

    Full-endoscopic posterior foraminotomy surgery for cervical disc herniations.

    Operative Orthopadie und Traumatologie·2018
    Same author

    [Grip strength measurement : Significance and boundaries].

    Der Orthopade·2017
    Same author

    [Arthrodesis of the distal interphalangeal joint using the headless compression screw].

    Operative Orthopadie und Traumatologie·2017
    Same journal

    Prevalence of two tumor necrosis factor gene polymorphisms in premature infants with early onset sepsis.

    Biology of the neonate·2006
    Same journal

    Can cerebrospinal fluid uric acid levels differentiate intraventricular hemorrhage from traumatic tap?

    Biology of the neonate·2006
    Same journal

    Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain.

    Biology of the neonate·2006
    Same journal

    Thymus involution and cerebral white matter damage in extremely low gestational age neonates.

    Biology of the neonate·2006
    Same journal

    Primary repair of esophageal atresia in extremely low birth weight infants: a single-center experience and review of the literature.

    Biology of the neonate·2006
    Same journal

    Systemic and pulmonary effects of vasopressors and inotropes in the neonate.

    Biology of the neonate·2006
    See all related articles

    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Animal Physiology

    Background:

    • Mevalonate is a key precursor in cholesterol biosynthesis.
    • Understanding mevalonate metabolism is crucial for studying lipid metabolism and related disorders.
    • Developmental changes in metabolic pathways can impact overall health and disease susceptibility.

    Purpose of the Study:

    • To investigate the developmental changes in mevalonate oxidation in vivo and in vitro in rats.
    • To determine the specific role of kidney tissue in mevalonate metabolism during development.
    • To identify any sex-specific differences in mevalonate oxidation rates during the post-weaning period.

    Main Methods:

    • Utilized 2-14C-mevalonate to trace oxidation rates in vivo in rats of different ages (1-3 days old and adults).

    Related Experiment Videos

  • Assessed mevalonate oxidation rates in isolated kidney slices from rats at various developmental stages.
  • Compared oxidation rates between male and female rats, particularly around the time of weaning.

    • Main Results:

    • In vivo oxidation of 2-14C-mevalonate was significantly low in 1- to 3-day-old rats, gradually increasing to adult levels.
    • Kidney slices demonstrated a consistent rate of mevalonate oxidation throughout the studied developmental period.
    • A transient, significant increase in mevalonate oxidation rate was observed specifically in male rats at the time of weaning.

    Conclusions:

    • Mevalonate oxidation in vivo is tightly regulated during rat development, reaching adult levels post-weaning.
    • Kidney tissue maintains a stable mevalonate oxidation capacity across different developmental stages.
    • Male rats exhibit a transient, sex-specific surge in mevalonate oxidation during the critical weaning phase, suggesting unique metabolic adaptations.