Non-stationary analysis of molecule capture and translocation in nanopore arrays
Ilya Sychugov1, Miao Zhang1, Jan Linnros1
1Department of Applied Physics, School of Engineering Sciences, KTH-Royal Institute of Technology, 16440 Kista-Stockholm, Sweden.
Abstract:
Analytical formulas for the ON- and OFF-time distributions as well as for the autocorrelation function were derived for the case of single molecule translocation through nanopore arrays. The obtained time-dependent expressions describe very well experimentally recorded statistics of DNA translocations through an array of solid state nanopores, which allows us to extract molecule and system related physical parameters from the experimental traces. The necessity of non-stationary analysis as opposite to the steady-state approximation has been vindicated for the molecule capture process, where different time-dependent regimes were identified. A long tail in the distribution of translocation times has been rationalized invoking Markov jumps, where a possible sequential ordering of events was elucidated through autocorrelation function analysis.
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