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Platelet storage pool deficiency in pigs.

T M Daniels, D N Fass, J G White

    Blood
    |April 1, 1986
    PubMed
    Summary
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    A novel bleeding disorder, storage pool deficiency (SPD) of platelets, was identified in pigs. SPD pigs exhibit severe bleeding, unlike normal carriers, due to platelet defects.

    Area of Science:

    • Veterinary Medicine
    • Hematology
    • Genetics

    Background:

    • The Mayo swine colony harbors pigs with von Willebrand's disease (vWD).
    • A subset of these pigs exhibits a distinct bleeding disorder, termed storage pool deficiency (SPD).

    Purpose of the Study:

    • To characterize a newly identified bleeding disease, storage pool deficiency (SPD), in pigs.
    • To investigate the underlying mechanisms and inheritance pattern of SPD.

    Main Methods:

    • Comparative analysis of vWD carriers and SPD pigs.
    • Platelet function tests including aggregation, serotonin uptake, and content analysis.
    • Transmission electron microscopy to examine platelet ultrastructure.
    • Genetic analysis to determine the mode of inheritance.

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    Main Results:

    • SPD pigs displayed prolonged bleeding times (>15 minutes) and severe bleeding, contrasting with normal vWD carriers.
    • Reduced platelet aggregation to collagen was observed in most SPD pigs.
    • SPD platelets showed diminished content of ADP, ATP, and serotonin, with impaired serotonin retention.
    • Transmission electron microscopy revealed a significant reduction in platelet dense bodies in SPD pigs.
    • Genetic analysis indicated an autosomal recessive inheritance pattern for SPD.

    Conclusions:

    • The findings confirm a diagnosis of storage pool deficiency (SPD) in affected pigs.
    • SPD is characterized by platelet dense body deficiency and impaired serotonin storage.
    • The condition follows an autosomal recessive inheritance pattern.
    • Ongoing breeding programs aim to isolate and further study the SPD gene and affected pigs.