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Pediatric trauma-related coagulopathy: Balanced resuscitation, goal-directed therapy and viscoelastic assays
Natalie A Drucker1, S Keisin Wang1, Christopher Newton2
1Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children, Indianapolis, IN, United States.
Insights
Research on pediatric trauma-induced coagulopathy is limited, necessitating further investigation into age-related hemostasis and balanced resuscitation strategies for improved hemorrhage control.
Area of Science:
- Pediatric critical care medicine
- Trauma surgery
- Hematology
Background:
- Trauma-induced coagulopathy understanding has advanced adult damage-control resuscitation.
- Pediatric trauma research on coagulopathy and resuscitation remains sparse.
- There is a significant need for more evidence in pediatric trauma care.
Purpose of the Study:
- To review current pediatric data on trauma-induced coagulopathy.
- To examine applicable adult data for pediatric relevance.
- To identify future research areas impacting pediatric trauma care.
Main Methods:
- Literature review of pediatric trauma-induced coagulopathy.
- Analysis of adult data applicable to pediatric populations.
- Identification of emerging research topics in pediatric hemostasis.
Main Results:
- Limited evidence exists for pediatric trauma-induced coagulopathy.
- Age-related hemostatic differences require further study.
- Advances in coagulation assays and medications like tranexamic acid show promise.
Conclusions:
- Pediatric trauma care requires tailored approaches to coagulopathy.
- Further research is crucial for optimizing resuscitation strategies.
- Future investigations will focus on age-specific hemostasis and hemorrhage control.
Abstract:
The improved understanding of trauma-induced coagulopathy in adults has led to an evolution in the strategies of damage-control resuscitation. While its impact on the care of pediatric trauma patients is of tremendous interest, the evidence is sparse, and a great deal of research is still needed in this domain. Areas of particular interest include age-related differences in hemostasis and balanced resuscitation, advances in functional coagulation assays and effective adjunctive medications, such as tranexamic acid, for hemorrhage control. This review examines the available pediatric data, reviews applicable adult data, and introduces areas of investigation that will impact pediatric trauma care in the future.
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