Related Experiment Video
Updated: Jan 28, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations
G Petringa1, F Romano2, L Manti3
1INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; Dipartimento di Fisica e Astronomia, Universitá degli Studi di Catania, Via S. Sofia 64, 95123 Catania, Italy.
Purpose:
The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams.
Methods:
The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data.
Results And Conclusions:
The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
More Related Videos
09:17Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
Published on: March 1, 2022
06:09P300-Based Brain-Computer Interface Speller Performance Estimation with Classifier-Based Latency Estimation
Published on: September 8, 2023
Related Concept Videos
Estimation of the Physical Quantities
Base Quantities and Derived Quantities
The International Organization for...
Reliability and Validity
What are Estimates?
The estimate for the mean of a sample is denoted by ͞x, whereas the mean of the population is designated as μ. Further, parameters such...
Relating Angular And Linear Quantities - I
When comparing the linear and rotational variables individually, the linear variable of position has physical units of meters, whereas the angular position variable has dimensionless units of radians, as it is the ratio of two lengths. The linear velocity...
Relating Angular And Linear Quantities - II