[Diagnostic challenge of biphenotypic sinonasal sarcoma]
Related Experiment Video
Updated: Jan 28, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Nazim Benzerdjeb1, Juliet Tantot2, Fatima Ameur3
1Centre de biologie sud, centre hospitalier sud, institut de pathologie multisite, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69310 Pierre-Bénite, France; Université Claude-Bernard Lyon I, 43, boulevard du 11-Novembre-1918, 69100 Villeurbanne cedex, France.
Abstract:
Sinonasal biphenotypic sarcoma has recently been described and included in the 2017 WHO classification. It is a low-grade sarcoma which is characterized by PAX3 rearrangements. It remains a diagnostic challenge because of its scarcity, and its considerable histologic overlap with other cellular spindle cell neoplasms. The histologic features, the immunoprofile and the main differential diagnoses of sinonasal biphenotypic sarcoma are presented through a case.
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