Managing treatment fluctuations in Parkinson disease: "On" again-, "off" again

W Steven Metzer¹, Filipe B Rodrigues²

• ¹From the Department of Neurology (W.S.M.), University of Arkansas for Medical Sciences, Little Rock; UCL Huntington's Disease Centre (F.B.R.), UCL Queen Square Institute of Neurology, London, UK; Clinical Pharmacology Unit (F.B.R.), Instituto de Medicina Molecular, Lisbon; and Laboratory of Clinical Pharmacology and Therapeutics (F.B.R.), Faculty of Medicine, University of Lisbon, Portugal. wsmetzer@UAMS.edu.+1