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A chemically fuelled self-replicator.

Sarah M Morrow1, Ignacio Colomer1, Stephen P Fletcher2

  • 1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

Nature Communications
|March 3, 2019
PubMed
Summary
This summary is machine-generated.

Researchers created a lifelike system using chemical energy to power a self-replicating surfactant. This system mimics metabolic cycles, maintaining replicators out-of-equilibrium and responsive to fuel supply.

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Area of Science:

  • Chemical Biology
  • Origin of Life Studies
  • Supramolecular Chemistry

Background:

  • Biological systems rely on continuous chemical energy consumption for function.
  • Understanding the transition from non-living chemical mixtures to emergent lifelike systems is a key scientific goal.

Purpose of the Study:

  • To engineer a self-replicating system powered by chemical energy.
  • To investigate the creation of lifelike materials and machines from simple chemical components.

Main Methods:

  • Utilizing an autocatalytic process for metastable surfactant formation.
  • Employing a chemical fuel to regenerate building blocks from surfactant breakdown products.
  • Maintaining the system out-of-equilibrium through continuous fuel consumption.

Main Results:

  • A replicator system was sustained out-of-equilibrium by continuous chemical energy.
  • The system demonstrated a steady-state persistence of high-energy replicators, analogous to metabolic cycles.
  • Replicator concentration was higher than in closed systems and responsive to fuel supply rate.

Conclusions:

  • Continuous chemical energy consumption can maintain non-equilibrium self-replicating systems.
  • This work provides insights into the emergence of lifelike behaviors from chemical components.
  • The engineered system serves as a model for understanding metabolic cycles and self-replication.