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Updated: Jan 28, 2026

Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages
Published on: May 24, 2019
Measuring Apoptotic Cell Engulfment (Efferocytosis) Efficiency
1Division of Medicine, Centre for Cardiometabolic Medicine, University College of London, London, UK. m.gage@ucl.ac.uk.
Abstract:
Efferocytosis is the process of recognizing and removing dead and dying cells, performed by a variety of phagocytic cells including macrophages. It has recently been shown that liver X receptor (LXR) signaling in macrophages regulates the expression of important efferocytosis receptors, bridging and signaling molecules. Here we describe a sensitive yet robust efferocytosis assay, optimized to measure bone marrow-derived macrophage (BMDM) apoptotic cell engulfment capability. This assay can be applied to genetically or pharmacologically altered BMDMs.
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