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Updated: Jan 28, 2026

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model
Published on: January 19, 2024
Dealing with an insufficient future liver remnant: Portal vein embolization and two-stage hepatectomy
Yoshikuni Kawaguchi1, Heather A Lillemoe1, Jean-Nicolas Vauthey1
1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Abstract:
Colorectal liver metastases (CLM) are not always resectable at the time of diagnosis. An insufficient future liver remnant is a factor excluding patients from curative intent resection. To deal with this issue, two-stage hepatectomy was introduced approximately 20 years ago. It is a sequential treatment strategy for bilateral CLM, which consists of preoperative chemotherapy, portal vein embolization, and planned first and second liver resections. This study reviews current evidence supporting use of two-stage hepatectomy.
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