Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic active hepatitis and related disorders.

V Larcher

    Clinics in Gastroenterology
    |January 1, 1986
    PubMed
    Summary

    Diagnosing chronic hepatitis in children requires prompt investigation into its cause, especially distinguishing between autoimmune and hepatitis B virus (HBV)-associated chronic active hepatitis (CAH). Early diagnosis and treatment of autoimmune CAH can prevent long-term liver damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gene therapy for children with cystic fibrosis--who has the right to choose?

    Journal of medical ethics·2006
    Same author

    Decision making and modes of death in a tertiary neonatal unit.

    Archives of disease in childhood. Fetal and neonatal edition·2004
    Same author

    Semen collection from young cancer patients.

    Human fertility (Cambridge, England)·2001
    Same author

    Fertility preservation for children treated for cancer (1): scientific advances and research dilemmas.

    Archives of disease in childhood·2001
    Same author

    Fertility preservation for children treated for cancer (2): ethics of consent for gamete storage and experimentation.

    Archives of disease in childhood·2001
    Same author

    Schistosoma haematobium infection in children in Britain.

    BJU international·2000

    Area of Science:

    • Pediatric Hepatology
    • Immunology
    • Gastroenterology

    Background:

    • Chronic hepatitis in children necessitates prompt investigation if symptoms persist over a month after acute hepatitis, or if relapsing hepatitis or chronic liver disease features are present.
    • Excluding specific etiologies like hepatitis B virus (HBV), Wilson's disease, and alpha-1-antitrypsin deficiency is crucial for accurate diagnosis.
    • Early histological confirmation by a pathologist is mandatory for effective management.

    Purpose of the Study:

    • To differentiate between autoimmune and HBV-associated chronic active hepatitis (CAH) in pediatric patients.
    • To highlight the distinct clinical presentation and treatment response of autoimmune CAH in children compared to adults.
    • To emphasize the importance of early diagnosis and intervention in preventing long-term sequelae like cirrhosis.

    Main Methods:

    • Clinical feature analysis and liver function test monitoring.
    • Etiological investigations including exclusion of specific diseases (e.g., HBV, Wilson's disease).
    • Histopathological examination for diagnosis and classification of chronic hepatitis.
    • Immunological studies investigating T suppressor cell defects and antibody-dependent cytotoxicity in autoimmune CAH.

    Main Results:

    • Autoimmune CAH in children often presents acutely with a favorable response to immunosuppressants, allowing for potential therapy withdrawal if diagnosed early.
    • HBV-associated CAH may show poor response to immunosuppressants, with undefined therapeutic regimens.
    • Early diagnosis and treatment of autoimmune CAH may reduce the incidence of cirrhosis.

    Conclusions:

    • Distinguishing between autoimmune and HBV-associated CAH is critical for appropriate pediatric management.
    • Early intervention in autoimmune CAH offers a better prognosis, potentially preventing cirrhosis.
    • Further research into cellular interactions in hepatic fibrosis is needed for novel therapeutic strategies.

    Related Experiment Videos