Related Experiment Video

Updated: Jan 28, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K

Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer

Mirco Compagnone1, Loredana Cifaldi2, Doriana Fruci1

  • 1Paediatric Haematology/Oncology Department, Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy.

Human Immunology
|March 3, 2019
PubMed

Insights

Endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 are crucial for peptide trimming. Their altered expression in tumors impacts cancer immunity, affecting immune cell responses.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cancer Research

Background:

  • Endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim substrates for MHC class I peptide generation.
  • Absence of ERAP enzymes alters cell surface peptides, influencing NK and CD8+ T cell responses.
  • ERAP1 and ERAP2 expression is frequently dysregulated in tumors.

Purpose of the Study:

  • To review current knowledge on ERAP1 and ERAP2 regulation.
  • To discuss the role of ERAP1 and ERAP2 in cancer immunity.
  • To highlight recent findings on ERAP enzymes in tumor immunology.

Main Methods:

  • Literature review of transcriptional and post-transcriptional regulations.
  • Analysis of recent studies on ERAP1 and ERAP2 in cancer.
  • Discussion of ERAP enzyme function in immune responses.

Main Results:

  • ERAP enzymes are critical for generating MHC class I binding peptides.
  • Altered ERAP expression in tumors can modulate anti-tumor immunity.
  • ERAP dysregulation affects the peptide repertoire presented to immune cells.

Conclusions:

  • ERAP1 and ERAP2 play a significant role in cancer immunity.
  • Understanding ERAP regulation is key to developing cancer immunotherapies.
  • Further research is needed to fully elucidate ERAP's impact on tumor growth and immune surveillance.
Keywords:
AminopeptidaseAntigen processingCancerGenetic alterationsTranscription factors

More Related Videos

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.9K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K

Related Concept Videos

Gene Regulation During Sporulation01:17

Gene Regulation During Sporulation

Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...
491
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
1.1K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.8K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K