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Australeols A-F, neuroprotective meroterpenoids from Ganoderma australe
Jiao-Jiao Zhang1, Yun Dong2, Fu-Ying Qin1
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
Abstract:
Six new meroterpenoids, australeols A-F (1-6), together with nineteen known compounds (7-25), were isolated from the fruiting bodies of Ganoderma australe. Their structures including absolute configurations were assigned by using spectroscopic methods, CD comparison, and X-ray crystallography analysis. Biological evaluation reveals that compounds 13, (-)-19, and 23 exhibit potent neuroprotective activities in glutamate-stimulated SH-SY5Y cells.
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