Related Experiment Video
Updated: Jan 28, 2026
05:59
Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion
Published on: March 3, 2014
12.5K
Spinal Cord Protection for Thoracic Aortic Surgery: Bench to Bedside
Christian V Ghincea1, Yuki Ikeno1, Muhammad Aftab1
1Department of Surgery, Division of Cardiothoracic Surgery, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado.
Seminars in Thoracic and Cardiovascular Surgery
|March 3, 2019
Summary
This study explores spinal cord injury pathophysiology and ischemia reperfusion effects. Strategies to maximize blood flow, improve tolerance, and promote collateralization are key for neuroprotection in complex aortic disease management.
Area of Science:
- Neurology
- Cardiovascular Surgery
- Cellular Biology
Background:
- Spinal cord injury (SCI) pathophysiology involves complex vascular dynamics.
- Ischemia reperfusion injury significantly impacts cellular function post-SCI.
- Management of complex aortic disease presents challenges in spinal cord protection.
Purpose of the Study:
- To summarize the pathophysiology of SCI.
- To review neuroprotective strategies and pharmacologic interventions.
- To highlight research in neuronal ischemic tolerance and collateralization.
Main Methods:
- Review of anatomically driven pathophysiology of SCI.
- Analysis of ischemia reperfusion impact on cellular level.
- Examination of neuroprotective strategies and pharmacologic interventions.
Main Results:
- Spinal cord malperfusion and disrupted collateral blood flow are central to SCI pathophysiology.
- Neuronal ischemic tolerance and promotion of collateralization are critical research areas.
- Integrated strategies maximizing spinal cord blood flow are optimal for protection.
Conclusions:
- An integrated, protocolized approach is optimal for spinal cord protection.
- Continued laboratory research is needed for a granular understanding of ischemic injury.
- Translating protective therapies from the lab to clinical practice remains a challenge.
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