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Stillbirth and factor V Leiden - A regional based prospective evaluation
Ida Björk1, Karin Pettersson2, Pelle G Lindqvist3
1Departments Obstetrics and Gynecology, Sodertalje Hospital, Sodertalje, Sweden.
Thrombosis Research
|March 3, 2019
Summary
Coagulation factor V Leiden (FVL) carriership in mothers did not increase stillbirth risk. However, FVL carriers were less likely to have stillbirths caused by infection.
Area of Science:
- Reproductive Health
- Genetics
- Obstetrics
Background:
- Coagulation factor V Leiden (FVL) affects approximately 10% of Swedes.
- FVL carriership has been controversially linked to an increased risk of stillbirth.
- This study investigated the association between FVL carriership and stillbirth risk.
Purpose of the Study:
- To determine if maternal FVL carriership is associated with an increased risk of stillbirth.
- To compare FVL carrier status in stillbirth cases versus live births.
- To explore potential differences in causes of stillbirth between FVL carriers and non-carriers.
Main Methods:
- A population-based study in the Stockholm region from 2001-2015.
- Inclusion of all stillbirths and a control group of live births.
- FVL blood testing, autopsy, and placental examination for stillbirth cases.
Main Results:
- The stillbirth incidence was 3.6‰.
- FVL carrier rates were similar between stillbirth cases (7.7%) and controls (8.1%).
- Infections were less common as a primary cause of stillbirth among FVL carriers (OR=2.3).
Conclusions:
- Maternal FVL carriership is not associated with an increased risk of stillbirth.
- FVL carriership may be associated with a reduced likelihood of stillbirth due to infection.
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