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Pilot Study to Evaluate the Adjunct Use of a Povidone-Iodine Topical Antiseptic in Patients with Soft Tissue

Adriana Segura Olson1, Lauren Rosenblatt2, Nicholas Salerno2

  • 1Department of Medicine, Section of Emergency Medicine, University of Chicago, Chicago, Illinois.

The Journal of Emergency Medicine
|March 4, 2019
PubMed
Abstract

Insights

Povidone-iodine (PVP-I) did not improve clinical cure rates for skin abscesses compared to standard care. The addition of PVP-I was associated with a higher rate of local skin irritation.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Clinical Research

Background:

  • Povidone-iodine (PVP-I) exhibits efficacy against methicillin-resistant Staphylococcus aureus (MRSA).
  • MRSA is a frequent cause of superficial skin abscesses.

Purpose of the Study:

  • To assess the feasibility of using PVP-I as an adjunctive treatment for superficial skin abscesses.
  • To compare the efficacy of PVP-I plus incision and drainage (I&D) against I&D alone.

Main Methods:

  • A randomized controlled pilot study was conducted on adult patients with uncomplicated skin abscesses.
  • Patients received either PVP-I adjunct therapy or standard care, alongside I&D and abscess packing.
  • Outcomes included clinical cure rates at 7-10 days and secondary assessments of new lesions and household contact spread.

Main Results:

  • Clinical cure rates were similar between the PVP-I group (88.2%) and the standard care group (91.3%).
  • The PVP-I group experienced a significantly higher incidence of adverse events (59.6%) compared to standard care (26.5%).
  • Local skin irritation was a common adverse event associated with PVP-I use.

Conclusions:

  • PVP-I does not offer a clinical cure benefit when used as an adjunct to I&D for skin abscesses.
  • While no major adverse events were reported, PVP-I use led to increased local skin irritation.
  • Standard care remains the recommended treatment approach for uncomplicated skin abscesses.
Keywords:
abscessantisepticiodinepovidonewound care

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