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Meningococcal C vaccine coverage in France in infants, children, and adolescents
J Gaudelus1, R Cohen2, B Leboucher3
1Service de pédiatrie, hôpital Jean-Verdier, 93140 Bondy, France; Université Paris-XIII, 93017 Bobigny, France.
Insights
Meningococcal C vaccination coverage in France remains insufficient for herd immunity, necessitating improved strategies. A new recommendation for infant vaccination at 5 months shows promise for increasing coverage and preventing disease.
Area of Science:
- Public Health
- Epidemiology
- Vaccinology
Background:
- Meningococcal C (MenC) vaccination was implemented in France in 2010 to reduce invasive meningococcal C disease (IMDC) incidence via herd immunity.
- The Vaccinoscopie survey monitors vaccination coverage rates (VCRs) in children.
Purpose of the Study:
- To assess MenC vaccination coverage rates and parental perceptions in France.
- To evaluate the impact of the 2017 vaccine calendar update recommending MenC vaccination for infants.
Main Methods:
- Annual online survey using self-administered questionnaires completed by mothers.
- Data collected in 2017 from 4500 mothers on child vaccinations.
- Analysis of VCRs across different age groups and influencing factors.
Main Results:
- 77%-84% of mothers found MenC vaccination indispensable or useful; fear of adverse effects was a key barrier.
- VCRs were 77% (24-35 months), 79% (6 years), and 50% (14-15 years).
- Six months post-recommendation, 43% of infants received the MenC vaccine by 6 months.
Conclusions:
- Current MenC VCRs are insufficient to achieve herd immunity in France.
- Over 100 deaths could have been avoided between 2011-2017 with optimal VCRs.
- The new 5-month infant recommendation and 2018 mandatory vaccination are expected to significantly reduce IMDC incidence.
Objectives:
Meningococcal C (MenC) vaccination was introduced in the French vaccination calendar in 2010 to reduce the incidence of invasive meningococcal C disease (IMDC), mainly through herd immunity. The Vaccinoscopie survey helps follow vaccination coverage rates (VCRs) of children.
Methods:
This annual survey is based on a self-administered online questionnaire. In 2017, 4500 mothers of children completed the questionnaire and reported all vaccinations recorded in their child's health record.
Results:
MenC vaccination was deemed indispensable or useful by 77% to 84% of mothers. The main barrier mentioned by mothers considering the vaccination useless/not very useful, was fear of adverse effects. VCR was estimated at 77% among 24-35-month-old infants, 79% among 6-year-old children, and 50% among 14-15-year-old adolescents. VCR strongly varied depending on the physician's advice for vaccination and on the type of follow-up. Six months after publication of the new French vaccine calendar in April 2017, with a MenC vaccine recommendation for all 5-month-old infants, 43% of infants had received a dose at 6 months of age.
Conclusions:
VCRs are insufficient to reach herd immunity. Between 2011 and 2017 more than 100 deaths could have been avoided in France if optimal VCRs had been achieved. Faced with this vaccine strategy failure, the new vaccine recommendation at 5 months of age seems well-accepted. This recommendation and the implementation of infant mandatory vaccination in 2018 should have a major impact on IMD C incidence in this age group.
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