Related Experiment Video

Updated: Aug 15, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

Cardioventilator effects of TRH in anaesthetized rats: role of the brain stem

I Paakkari, M L Nurminen, A L Sirén

    European Journal of Pharmacology
    |March 11, 1986
    PubMed

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    Physiological Control of Respiration01:23

    Physiological Control of Respiration

    Introduction
    Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
    Regulation of Ventilation
    The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
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    Neural Control of Respiration

    The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
    Respiratory Centers in the Brainstem
    Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
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    Chemical Factors Affecting Respiration Centers

    Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
    CO2 has a potent influence on respiration and is strictly regulated. Under...
    Other Factors Affecting Respiration Centers01:17

    Other Factors Affecting Respiration Centers

    Breathing is primarily an involuntary activity regulated by the brainstem respiratory centers. However, it can also be consciously controlled, allowing us to hold our breath or take deeper breaths when needed. This voluntary control is facilitated by the cerebral motor cortex, which bypasses the medullary centers to stimulate the respiratory muscles directly.
    However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical level,...
    Physiology of Respiration II: Neurogenic Control of Respiration01:22

    Physiology of Respiration II: Neurogenic Control of Respiration

    The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
    Central Control
    The brainstem is the primary site of central control, hosting respiratory centers: