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Renal function in prepubertal children born with very low birthweight
Simone Holzer1, Denise de Oliveira Schoeps1, Fabiola Isabel Suano-Souza2
1Department of Pediatrics, Faculdade de Medicina do ABC, Santo Andre, Brazil.
Nutrition (Burbank, Los Angeles County, Calif.)
|March 4, 2019
Summary
Children born with very low birthweight (VLBW) show normal kidney function and estimated glomerular filtration rates (eGFR) in prepuberty. Nutritional status, including obesity, did not impact these renal markers in VLBW children.
Area of Science:
- Pediatric Nephrology
- Neonatology
- Public Health
Background:
- Very low birthweight (VLBW) is associated with potential long-term health complications.
- Renal function and nutritional status are critical indicators of child development.
Purpose of the Study:
- To assess estimated glomerular filtration rates (eGFR) and renal function markers in prepubertal children born with VLBW.
- To investigate the relationship between renal parameters and current nutritional status in VLBW children.
Main Methods:
- Cross-sectional study comparing 44 VLBW children with 30 healthy, full-term controls (ages 5-10).
- Collected perinatal data, anthropometrics, blood pressure, and blood/urine markers of renal function (creatinine, cystatin-C, albuminuria, etc.).
Main Results:
- No significant differences in blood pressure, eGFR, albuminuria, or other renal markers between VLBW and control groups.
- Within the VLBW group, overweight/obese children showed no difference in renal injury markers compared to normal BMI peers.
Conclusions:
- Prepubertal children born with VLBW exhibit preserved renal function.
- Renal function in VLBW children is not adversely affected by their current nutritional status.
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