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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

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Label-free and reagentless capacitive aptasensor for thrombin.

Hsin-Ju Chen¹, Richie L C Chen¹, Bo-Chuan Hsieh¹

¹Department of Bio-Industrial Mechatronics Engineering, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.

Biosensors & Bioelectronics

|March 4, 2019

Summary

This study presents a novel label-free aptasensor for detecting thrombin. The device utilizes a capacitive transducer and self-assembled monolayers, achieving high sensitivity for point-of-care diagnostics.

Keywords:

Aptamer Capacitive Self-assembly monolayer (SAM)Switched capacitor (SC)Thrombin

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Published on: July 30, 2013

Area of Science:

Biosensing and nanotechnology
Electrochemical biosensors
Surface chemistry

Background:

Label-free and reagentless biosensors are crucial for efficient clinical diagnostics.
Capacitive transducers offer a sensitive platform for detecting biomolecular interactions.
Self-assembled monolayers (SAMs) are effective for surface functionalization and preventing non-specific binding.

Purpose of the Study:

To develop a novel label-free and reagentless aptasensor for ultrasensitive thrombin detection.
To utilize a capacitive transducer with a self-assembled monolayer for enhanced biosensing performance.
To validate the aptasensor's efficacy in complex biological matrices for potential point-of-care applications.

Main Methods:

Fabrication of a capacitive transducer using gold and indium tin oxide electrodes.
Modification of gold electrodes with aptamers and 1-dodecanethiol to form a self-assembled monolayer (SAM).
Utilizing a switched capacitor (SC) circuit for precise capacitance measurements upon analyte binding.

Main Results:

The SAM effectively insulated the electrode surface, enabling capacitive sensing.
The aptasensor demonstrated high sensitivity for thrombin detection, with limits as low as 1 pM in PBS.
Linear detection range for thrombin in human serum was 10 pM to 1 μM (R²=0.98).
Minimal non-specific binding observed with common proteins like BSA and HSA.

Conclusions:

The developed aptasensor offers a promising platform for ultrasensitive, label-free, and reagentless detection of thrombin.
The combination of switched capacitor technology and SAMs advances capacitive transduction for biosensing.
This technology holds potential for point-of-care clinical analysis using minimal biological samples.