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Updated: Jan 28, 2026
An Efficient Method for Adenovirus Production
Published on: June 10, 2021
Adenovirus cerebellitis in an immunocompetent 2-year-old girl
Zena Tansley-Ahmed1, Kit Wu2, Loucas Christodoulou3
1Department of Paediatrics, University College London Medical School, Royal Free Hospital NHS Trust, London, UK.
Insights
Adenovirus is a rare cause of acute cerebellitis (AC) in children, often following respiratory infections. Early neuroimaging is crucial for diagnosis and favorable outcomes in pediatric acute cerebellar dysfunction.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Neuroimaging
Background:
- Acute cerebellitis (AC) is a primary cause of acute cerebellar dysfunction in children.
- While typically benign, AC can lead to severe complications like hydrocephalus and brainstem compression.
- Prompt diagnosis of AC is critical for effective management and preventing adverse outcomes.
Abstract:
Acute cerebellitis (AC) is a principal cause of acute cerebellar dysfunction in previously well children. Although the condition is usually benign, fatal complications include obstructive hydrocephalus and brainstem compression; therefore, prompt accurate diagnosis is vital. 1 There are various pathogens reported in the literature as aetiological agents of AC; however, adenovirus is very rarely mentioned, with only one previous case report in the literature to the best of our knowledge. 2 This case demonstrates the importance of recognising adenovirus as a cause of AC, particularly when preceded by a respiratory tract infection in the paediatric age group. Furthermore, we highlight the role of early neuroimaging in differentiating AC from other causes of acute cerebellar dysfunction, which require different management. Our patient made a full recovery with no long-term deficits demonstrating that comprehensive investigation and consideration of atypical pathogens in the context of AC is vital in securing a favourable outcome.
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