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The Correlation between Osteoporosis and Blood Circulation Function Based on Magnetic Resonance Imaging
Xiaoming Qiu1, Yufei Fu2, Jiao Chen2
1Department of Radiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, No.141 Tianjin Road, Huangshi City, 435000, China. qxiaoming_edong@163.com.
Journal of Medical Systems
|March 4, 2019
Summary
Changes in blood circulation and oxygen metabolism in bone marrow and surrounding muscles are linked to bone mineral density loss. These circulatory changes, particularly in the tibial anterior muscle, are significant factors contributing to osteoporosis.
Area of Science:
- Biomedical Imaging
- Orthopedics
- Physiology
Background:
- Bone mineral density (BMD) loss, a hallmark of osteoporosis, is a growing public health concern.
- The relationship between altered blood circulation and the progression of osteoporosis remains incompletely understood.
- Tissue oxygen metabolism and bone marrow blood perfusion are critical physiological functions potentially linked to bone health.
Purpose of the Study:
- To investigate the association between changes in blood circulation, tissue oxygen metabolism, and bone mineral density (BMD).
- To identify specific physiological parameters of bone marrow blood perfusion and oxygen metabolism that correlate with BMD.
- To determine the independent effects of these physiological parameters on the risk of developing osteoporosis.
Main Methods:
- Utilized blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) to assess tissue oxygen metabolism parameters.
- Employed dynamic enhanced MRI (DCE-MRI) to obtain physiological parameters of bone marrow blood perfusion.
- Conducted correlation, variance, and multivariate logistic regression analyses using BMD as the dependent variable.
Main Results:
- Significant differences in oxygen metabolism were observed between muscles in different BMD groups and among different skeletal muscle fiber types.
- Age, total bone marrow volume, and the oxygen metabolism capacity of the tibial anterior muscle were found to have significant independent effects on osteoporosis.
- These findings indicate a direct link between impaired blood circulation in bone marrow and surrounding muscles and the development of osteoporosis.
Conclusions:
- Altered blood circulation in bone marrow and associated muscle tissues is a contributing factor to osteoporosis.
- BOLD-MRI and DCE-MRI are valuable tools for assessing physiological parameters related to bone health.
- Targeting circulatory and metabolic dysfunctions may offer novel therapeutic strategies for osteoporosis prevention and treatment.
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