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The STOP DIABETES study: when prevention works.

Aldo Bonaventura1,2, Fabrizio Montecucco3,4

  • 1First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132, Genoa, Italy. aldo.bonaventura@edu.unige.it.

Acta Diabetologica
|March 4, 2019
PubMed
Summary
This summary is machine-generated.

Preventing type 2 diabetes (T2D) requires early detection. The STOP DIABETES study found that intermediate and high-risk individuals significantly reduced T2D conversion through lifestyle changes and medication, highlighting the importance of early intervention.

Keywords:
1-h post-load plasma glucoseDiabetesOGTTPrediabetesPrevention

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Preventive Medicine

Background:

  • Diabetes prevention remains a significant public health challenge despite available treatments.
  • Prediabetes increases cardiovascular disease risk, underscoring the need for early detection and intervention.
  • The time lag between initial glycemic defects and diabetes complications necessitates prompt management.

Purpose of the Study:

  • To evaluate the effectiveness of risk stratification and tailored interventions in preventing type 2 diabetes (T2D).
  • To investigate the role of 1-hour plasma glucose concentration in early prediabetes detection.

Main Methods:

  • The STOP DIABETES study enrolled individuals at risk for T2D, assessing them via a 2-hour, 75-g oral glucose tolerance test (OGTT).
  • Participants were stratified into low, intermediate, and high-risk groups based on physiological responses.
  • Interventions included lifestyle modifications and pharmacological treatments tailored to risk level.

Main Results:

  • Individuals at intermediate and high risk showed the most significant reduction in T2D conversion rates.
  • A subset of individuals who developed T2D had normal baseline glucose tolerance but a 1-hour plasma glucose concentration exceeding 155 mg/dL.
  • Early detection of glycemic alterations allows for less intensive treatment and reduces long-term costs associated with diabetes and its complications.

Conclusions:

  • Risk stratification using OGTT, particularly considering the 1-hour plasma glucose concentration, enables early detection of individuals at risk for T2D.
  • Early identification and treatment of prediabetes can delay or prevent T2D onset and associated complications.
  • Incorporating 1-hour plasma glucose measurement into OGTT can improve early prediabetes diagnosis and management strategies.