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Updated: Jan 28, 2026
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
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Proton therapy for skull-base chondrosarcoma, a single-institution outcomes study
Adam L Holtzman1, Ronny L Rotondo2, Michael S Rutenberg2
1Department of Radiation Oncology, University of Florida College of Medicine, 2015 N Jefferson St, Jacksonville, FL, 32206, USA. aholtzman@floridaproton.org.
Journal of Neuro-Oncology
|March 4, 2019
Summary
External-beam proton therapy is effective for skull-base chondrosarcoma, showing high local control and survival rates. This treatment demonstrated no acute grade 3 radiation toxicity in a recent study.
Area of Science:
- Radiation Oncology
- Neurosurgery
- Medical Physics
Background:
- Skull-base chondrosarcomas are rare tumors requiring effective treatment strategies.
- Evaluating the efficacy of proton therapy for these tumors is crucial for improving patient outcomes.
Purpose of the Study:
- To assess the effectiveness of definitive or adjuvant external-beam proton therapy.
- To evaluate local control and survival rates in patients with skull-base chondrosarcoma.
Main Methods:
- Retrospective review of 43 patients treated with double-scattered 3D conformal proton therapy.
- Median follow-up of 3.7 years; toxicity scored using CTCAE v4.0.
Main Results:
- High-dose proton therapy (median 73.8 Gy[RBE]) showed excellent outcomes.
- At 4 years post-treatment, actuarial rates were 95% overall survival, 100% cause-specific survival, and 89% local control.
- No acute grade 3 radiation-related toxicities were observed.
Conclusions:
- High-dose proton therapy is an effective treatment for skull-base chondrosarcoma, yielding high local control rates.
- Proton therapy, alone or post-surgery, demonstrates a favorable safety profile with no acute grade 3 toxicity.
- Further long-term follow-up is needed to fully understand disease control and late toxicities.
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