[Dynamic tests in females with Kallmann syndrome]

Three patients with Kallmann's syndrome (one of whom had undergone eight-year therapy with sex steroids) were studied with many dynamic tests. The progesterone and clomiphene tests were negative. An insulin test and TRH stimulation test showed a normal pool of GH and TSH in the hypophysis. A double stimulation with 100 micrograms LH-RH led to an inadequate gonadotropin response with a dominant FSH secretion, while the patient who had previously received sex steroids gave better results. The other two patients received 100 micrograms LH-RH i.m. daily for 20 days and the double LH-RH stimulation test was repeated. A satisfactory gonadotropin response with a predominance of LH secretion was noted. A TRH stimulation test revealed normal PRL secretion, while after a chlorpromazine test only one patient showed a satisfactory PRL secretion. Under combined HMG-HCG therapy, one of the patients conceived and had a normal outcome of her pregnancy.