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Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma

Dominika Wolosz1, Agnieszka Walczak, Grzegorz Szparecki

  • 1Medical University of Warsaw, Department of Pathology. domi.wolosz@gmail.com.

European Journal of Histochemistry : EJH
|March 5, 2019
PubMed

Insights

Deleted in Liver Cancer 2 (DLC2) protein is not diminished in hepatocellular carcinoma. Instead, DLC2 is more abundant in tumors, suggesting different roles for DLC family members in cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Deleted in Liver Cancer (DLC) proteins are RhoGAP family members, negatively regulating Rho GTPases.
  • DLC1 is a known tumor suppressor in hepatocellular carcinoma (HCC).
  • The role of DLC2 in HCC remains unclear.

Purpose of the Study:

  • To investigate if DLC2 protein levels are reduced in hepatocellular carcinoma tissue.
  • To determine the gene status of DLC2 in HCC samples.

Main Methods:

  • Analysis of DLC2 protein expression in typical and fibrolamellar HCC tissues compared to non-cancerous liver specimens.
  • Assessment of DLC2 gene copy number in tumor samples.

Main Results:

  • DLC2 protein is not diminished in HCC tissue; it is often more abundant, especially in tumors with inflammation.
  • DLC2 gene status is diploid in most examined tumor samples.
  • DLC1 and DLC2 may have distinct functions in cancer despite structural similarities.

Conclusions:

  • DLC2 is not downregulated in hepatocellular carcinoma.
  • DLC2 expression is elevated in some HCC, particularly those with inflammatory components.
  • DLC family members exhibit differential roles in cancer progression.

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