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Atherosclerosis and Nanomedicine Potential: Current Advances and Future Opportunities
Fan Jiang1, Yunqi Zhu1, Changyang Gong2
1School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Abstract:
Atherosclerosis is the leading inducement of cardiovascular diseases, which ranks the first cause of global deaths. It is an arterial disease associated with dyslipidemia and changes in the composition of the vascular wall. Besides invasive surgical strategy, the current conservative clinical treatment for atherosclerosis falls into two categories, lipid regulating-based therapy and antiinflammatory therapy. However, the existing strategies based on conventional drug delivery systems have shown limited efficacy against disease development and plenty of side effects. Nanomedicine has great potential in the development of targeted therapy, controlled drug delivery and release, the design of novel specific drugs and diagnostic modalities, and biocompatible scaffolds with multifunctional characteristics, which has led to an evolution in the diagnosis and treatment of atherosclerosis. This paper will focus on the latest nanomedicine strategies for atherosclerosis diagnosis and treatment as well as discussing the potential therapeutic targets during atherosclerosis progress, which could form the basis of development of novel nanoplatform against atherosclerosis.
Insights
Nanomedicine offers advanced atherosclerosis diagnosis and treatment by enabling targeted drug delivery and novel therapies. This approach aims to overcome the limitations of conventional treatments for cardiovascular diseases.
Area of Science:
- Cardiovascular Research
- Nanomedicine Applications
- Arterial Disease Therapeutics
Background:
- Atherosclerosis is a primary cause of global mortality, characterized by arterial wall changes and dyslipidemia.
- Current treatments, including lipid-regulating and anti-inflammatory therapies, have limited efficacy and side effects.
- Conventional drug delivery systems are insufficient for managing atherosclerosis progression.
Purpose of the Study:
- To review the latest nanomedicine strategies for atherosclerosis diagnosis and treatment.
- To identify potential therapeutic targets in atherosclerosis progression.
- To explore the development of novel nanoplatforms for atherosclerosis management.
Main Methods:
- Review of recent advancements in nanomedicine for atherosclerosis.
- Analysis of nanomedicine-based targeted therapy and controlled drug delivery.
- Discussion of novel diagnostic modalities and biocompatible scaffolds.
Main Results:
- Nanomedicine enables targeted drug delivery, improving therapeutic efficacy for atherosclerosis.
- Novel nanoplatforms offer potential for early diagnosis and effective treatment.
- Biocompatible nanoscaffolds show promise for multifunctional therapeutic applications.
Conclusions:
- Nanomedicine represents a significant evolution in atherosclerosis diagnosis and treatment.
- Targeted therapies and advanced drug delivery systems are key nanomedicine contributions.
- Further research into nanoplatforms and therapeutic targets can lead to improved cardiovascular disease outcomes.
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