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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
Published on: September 11, 2020
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Translational Safety Biomarkers of Kidney Injury
Sean P Troth1, Katerina Vlasakova1, Shashi Amur2
1Merck Research Laboratories, Department of Safety Assessment and Laboratory Animal Resources, Merck & Co, Inc, West Point, PA.
Seminars in Nephrology
|March 5, 2019
Summary
Sensitive kidney injury biomarkers are advancing from research to clinical use. Recent progress supports their evaluation in drug development and clinical practice for better patient monitoring.
Area of Science:
- Nephrology
- Translational Medicine
- Biomarker Discovery
Background:
- Acute kidney injury (AKI) remains a significant clinical challenge.
- There is a critical need for sensitive biomarkers for monitoring kidney injury.
- Recent advancements have improved understanding of kidney injury mechanisms.
Purpose of the Study:
- To provide a comprehensive overview of kidney safety biomarker discovery and development.
- To highlight progress in nonclinical research and clinical translation.
- To discuss future opportunities in biomarker evaluation.
Main Methods:
- Review of recent literature on kidney biomarker research.
- Analysis of progress in preclinical and early clinical applications.
- Discussion of regulatory qualification pathways for biomarkers.
Main Results:
- Significant progress in identifying and evaluating novel kidney biomarkers.
- Successful clinical qualification of several accessible biomarker candidates.
- Increasing use of novel biomarkers in preclinical and early clinical settings.
Conclusions:
- Novel kidney biomarkers show promise for improved clinical monitoring of AKI.
- Continued evaluation may lead to broader regulatory approval and clinical adoption.
- The field is advancing towards more effective tools for kidney safety assessment.
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